Neural Interfacing Technologies
An interface connecting the brain to man-made electronics would enormously improve quality of life for persons with sensory and/or motor deficits caused by nerve damage. Silicon microelectrodes implanted directly into the brain are a step toward this goal and have already helped many patients, such as those with auditory prostheses.
Over time, however, these devices become less effective as the electrical signal recorded from the brain gradually loses strength. Why and how this happens is not yet well understood, but contributing factors may include inflammation, cell death, and encapsulation of electrodes in scar tissue.
Our laboratory is developing neuro-integrative coatings for silicon microelectrode arrays. Our coatings are neuro-adhesive and are capable of delivering trophic and anti-inflammatory agents in the vicinity of the electrodes. These agents promote integration and lessen the encapsulation response.
Different aspects of this research are funded by NINDS (R01 NS 045072) and NIDCD (R01 DC06849) respectively.
Sub-Projects
The Effects of Inflammation on Chronic Recording Reliability
- George McConnell
The Effects of Strain on Cortical Tissues
- Sharon Norman
Interfacing with Peripheral Nerves for Prosthetic Limb Control
- Isaac Clements