Targeted Drug and Contrast Agent Delivery
The state-of-the-art in targeted drug delivery today is 'local' delivery using biodegradable polymers. Our group is developing receptor targeted drug and contrast agents (for CT and MR imaging) such that targeting of diffuse, non-localized tissues is possible. In the long run we are interested in fashioning patient-specific targeting schemes, where a particular tissue's receptor profile is determined, and nano-scale liposomal vehicles with appropriate targeting regimens are fabricated in a very short time course to target the tissues of interest. Of particular interest to our group is the early detection and treatment of astrogliomas of the brain. This project is currently funded by the National Science Foundation (NSF 0201891) and the Georgia Tech-Emory Fund for Innovative Cancer Technologies.
Sub-Projects
MRI Contrast Agents for Enhancement of Tumors and Tumor Vasculature
- Ananta Laxmi Ayyagari
Targeted Liposomal Drug Delivery for the Treatment of Glioma In Vivo
- Katie McNeeley
CT Contrast Agents for Enhancement of Tumors and Tumor Vasculature
- Chen-Yu Kao
Glioma-selective delivery system
- Abhiruchi Agarwal
Novel contrast agent delivery system for brain tumor imaging
- Efstathios Karathanasis